Measurement of Immature Granulocytes (IG) Percentage to Assess Severe Bacterial Infection in Latvian Children: A Secondary Data Analysis

• DOI: 10.20944/preprints201804.0349.v1
• Publication Date: 2018-05-01T06:37:43Z
• Authors: Jana Pavare; Ilze Grope; Dace Gardovska
• Keywords: White blood cell

Background: Detection of small proportion serious bacterial infections (SBI) with potentially life threating course in a large group children fever admitted to emergency department (ED) is still complicated. Measurement immature granulocytes (IG) percentage may be used as marker infections. The aim the study was evaluate whether IG useful additional predictive SBI. Methods: This included 258 febrile ED. Clinical follow-up, microbiological and radiological tests were reference standards for definition Study population categorized into two groups: (i) infected patients no suspicion SBI (n = 75); (ii) 183). percentage, white blood cell count (WBC) C-reactive protein (CRP) levels analyzed from first routine samples at hospital admission. Results: A statistically significant difference observed those without - mean 1.2% group, 0.3% cutoff level predict 0.45 (84% specificity, 66% sensitivity, 90% positive value). We combine variables their additive values. sensitivity WBC detected improved 74% 85% when added prediction models. When CRP, combined, increased 93%, specificity 86%. (95% CI 77–93%). Receiver operator characteristic analysis showed an area under curve (AUC) 0.80 percentage. Conclusion: Addition traditionally markers CRP help identify Furthermore can rapidly obtained traditional full any extra sampling costs.