The Green Bitter Weed<em> (</em><em>Hymenoxys odorato) </em>Plant Extract Is Toxic to the Liver and Kidney of Wistar Rats<strong> </strong>

• DOI: 10.20944/preprints201806.0231.v1
• Publication Date: 2018-06-19T07:02:28Z
• Authors: John Juma Ochieng; Isaac Echoru; Musa Ajibola Iyiola
• Keywords: Aspartate transaminase; Transaminase

Background: Medicinal plants are of great importance to health individual and communities. About 80% the population in Uganda relies on traditional medicine because western-trained medical personnel limited especially villages. Most Ugandans use Hymenoxys odorato for medicinal purposes e.g. treat colds, fever, coughs, anti-helminthes, locally used as tea, anti-allergy also an anti-venom relieve snake bites. Method: A group 25 male wistar rats 150 g&amp;ndash;210 g were kept 14 days while being fed treated with extract. At 14th day, anesthesia was given blood samples collected by cardiac puncture hematological biochemical investigations. Serum analyzed Alkaline Phosphatase, Aspartate Transaminase Alanine whole complete count. The liver kidney removed placed 10% formalin prepare histology staining using haematoxylin eosin technique. Results: extract elevated hepatic biomarker enzymes i.e. ALP, ALT AST. increase found be significantly different (P &amp;gt; 0.05) at 400 500 mg/kg doses compared control group. Histological sections showed distortion cytoarchitecture, steatosis, necrosis hepatocytes congestion sinusoids high 300, body weight. In kidney, there mild integrity glomerular hypercellularity (400 per weight). Conclusion: aqueous has toxic effects rats. observed a dose dependent manner.