Silicon Photonic Biosensors Using Label-Free Detection

• DOI: 10.20944/preprints201809.0150.v1
• Publication Date: 2018-09-11T23:47:14Z
• Authors: Enxiao Luan; Hossam Shoman; Daniel M. Ratner; Karen C. Cheung; Lukas Chrostowski
• Keywords: Lab-on-a-Chip; Optofluidics; Waveguide

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose point-of-care diagnosis. In this review, we provide an overview state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, Bragg grating waveguide-based sensors. Their sensing mechanisms sensor performances, as well real biomarkers label-free detection, are exhibited compared. We also review development chip-level platforms, which consist device, flow delivery system, input readout equipment. At last, some system-level CMOS-chip packaging examples presented, indicating commercialization potential low cost, high yield, portable platform leveraging CMOS processes.