Fusaproliferin, a Fungal Phytotoxin Shows Rapid and Potent Cytotoxicity against Pancreatic Cancer Cell Lines

• DOI: 10.20944/preprints201810.0375.v1
• Publication Date: 2018-10-19T09:48:58Z
• Authors: Nazia Hoque; Choudhury Mahmood...; Md. Sohel Rana; Amrit Varsha; Md. Hossain Sohrab; Khondaker Miraz R...
• Keywords: Phytotoxin; Fusarium solani; Cancer cell lines; IC50

As a part of our ongoing research on endophytic fungi, we have isolated sesterterpene mycotoxin, fusaproliferin (FUS), from Fusarium solani strain associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic cancer cell lines. Time dependent survival analysis microscopy imaging morphological changes in lines 4 hours after incubation FUS. This provides new chemical scaffold that can be further developed to obtain more potent synthetic agents cancer.