Toxicity of TiO₂, ZnO and SiO₂ Nanoparticles in Human Lung Cells: Safe-By-Design Development of Construction Materials

• DOI: 10.20944/preprints201905.0281.v1
• Publication Date: 2019-05-24T06:43:48Z
• Authors: Monika Remzova; Radek Zouzelka; Tana Brzicova; Kristyna Vrbova; Dominik Pinkas; Pavel Rossner; Jan Topinka; Jiri Rathousky
• Keywords: Human lung; Viability assay

Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding their effects on human health and ecosystems. Here, we compare toxicological pristine TiO2, ZnO SiO2, coated SiO2 nanoparticles evaluate suitability as additives to consolidants weathered materials. First, WST-1 LDH assays were used determine viability alveolar A549 cells at various nanoparticle concentrations (0–250 μg mL−1). While TiO2 did exhibit any cytotoxic effect up highest tested concentration, significantly reduced cell viability. Second, all developed nanoparticle-modified increased mechanical strength sandstone, decisive criterion for selection most suitable additive was low toxicity possible. We believe that this approach will be high importance industry identify materials representing top functional properties an early stage product development.