Natural Products as Modulators of Sirtuins

• DOI: 10.20944/preprints202001.0324.v1
• Publication Date: 2020-01-29T09:47:06Z
• Authors: Berin Karaman Mayack; Wolfgang Sippl; Fidele Ntie-Kang
• Keywords: Natural product; Chemical space; Natural compound; Drug Development

Natural products have been used for the treatment of human diseases since ancient history. Over time, due to lack precise tools and techniques separation, purification, structural elucidation active constituents in natural resources there has a decline financial support efforts characterization products. Advances design chemical compounds understanding their functions is pharmacological importance biomedical field. However, regained attention as sources novel drug candidates upon recent developments progress technology. were shown bear an inherent ability bind biomacromolecules cover unparalleled space comparison most libraries high-throughput screening. Thus, hold great potential discovery new scaffolds therapeutic targets such Sirtuins. Sirtuins are Class III histone deacetylases that linked many Parkinson`s disease, Alzheimer’s type II diabetes, cancer aging. In this review, we examine revitalization interest discuss product modulators could serve starting point development isoform selective highly potent drug-like compounds.