Natural Products as Modulators of Sirtuins
Models, Molecular
0301 basic medicine
Biological Products
0303 health sciences
structure–activity relationship
epigenetics
natural products
medicinal_chemistry
Organic chemistry
Review
drug discovery
3. Good health
sirtuin
03 medical and health sciences
QD241-441
Drug Discovery
Animals
Humans
Sirtuins
Molecular Targeted Therapy
DOI:
10.20944/preprints202001.0324.v1
Publication Date:
2020-01-29T09:47:06Z
AUTHORS (3)
ABSTRACT
Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developments and progress in technology. Natural compounds were shown to bear an inherent ability to bind to biomacromolecules and cover an unparalleled chemical space in comparison to most libraries used for high-throughput screening. Thus, natural products hold a great potential for the drug discovery of new scaffolds for therapeutic targets such as Sirtuins. Sirtuins are Class III histone deacetylases that have been linked to many diseases such as Parkinson`s disease, Alzheimer’s disease, type II diabetes, and cancer linked to aging. In this review, we examine the revitalization of interest in natural products for drug discovery and discuss natural product modulators of Sirtuins that could serve as a starting point for the development of isoform selective and highly potent drug-like compounds.
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