CausalBuilder: Bringing the MI2CAST Causal Interaction Annotation Standard to the Curator

• DOI: 10.20944/preprints202007.0622.v1
• Publication Date: 2020-07-27T10:14:13Z
• Authors: Vasundra Touré; John Zobolas; Martin Kuiper; Steven Vercruysse
• Keywords: Interface (matter); Relevance; Representation

Molecular causal interactions are defined as regulatory connections between biological components. They commonly retrieved from experiments, and can be used for connecting molecules into computational models that represent systems. However, including a molecular interaction model requires assessing its relevance to model, based on detailed knowledge about the biomolecules, type, context. In order standardize representation of this in ‘causal statements’, we recently developed MI2CAST guidelines. Here introduce causalBuilder: an intuitive web-based curation interface annotation comply with standard. The causalBuilder prototype essentially embeds guidelines interface, makes rules easy follow by curator. addition, serves original application VSM general-purpose technology, provides both curators tool developers fully configured allow focusing selected concepts annotate. After information is entered, produces genuine statements exported different formats.