Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 Diabetes

• DOI: 10.20944/preprints202108.0506.v1
• Publication Date: 2021-08-27T08:14:05Z
• Authors: Daria Shunkina (S...; Alexandra Komar; Maria Vulf; Hung Vu Quang; Egor Shunkin; Elena Kirienkova; Anastasiia Dakchn...; Danil Malkov; Pavel Zatolokin; Larisa Litvinova
• Keywords: Adipose tissue macrophages

Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control survival, proliferation, differentiation, effector function immune cells. All components TNF are associated with NF-kB functions not limited to cell death may promote survival in face adipose tissue inflammation obesity. Inflammation pro-inflammatory dysfunction mitochondria key factors insulin resistance The aim study was analyze relationship soluble forms superfam-ily blood plasma mitochondrial dynamics (greater omentum (GO) subcutaneous (Sat)) obese patients without type 2 diabetes mellitus (T2DM). Increased sTNF-R1, sTNF-R2, sTNFRSF8 TNFSF12, TNFSF13, TNFSF13B characteristic T2DM. Increases TNFSF13B, sTNF-R1 levels decreased glucose concentration BMI patients. gene expression responsible for regulating were increased T2DM unbalanced obesity