Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Hospitalized Patients in Panama

• DOI: 10.20944/preprints202203.0187.v1
• Publication Date: 2022-03-15T07:55:39Z
• Authors: Viridiana Saenz; Lizette Carmen Gu...; Danilo Franco; Marlene Castillo; Brechla Moreno; Ediner Fuentes; Zeuz Capitan-Barrios; Sandra López-Vergès; Juan Miguel Pascale; Nestor Sosa; Leyda Ábrego
• Keywords: Panama; Neonatal Sepsis; Gastrointestinal system; Gold standard (test)

Human parechoviruses, officially known as Parechovirus A (PeV-A), from the family Picornaviri-dae, genus Parechovirus, are non-enveloped, icosahedral, positive-sense RNA viruses associated with mild gastrointestinal and respiratory illness in young children, however, they may also give rise to Central Nervous System (CNS) infections neonatal sepsis. While studies have delved into detection of HPeVs different populations, PeV-A Hispanic populations Latin American countries is not well-known. The aim this study was characterize circulating Republic Panama. Respiratory, neurological samples were collected 200 Panamanian pe-diatric patients hospitalized between 2014 2015 analyzed for presence by real-time RT-PCR. positive sequenced genetic characterization. These followed predetermined inclusion criteria negative viral/bacterial examinations that requested patient's physician when specimen sent ICGES. Eight (4%) detected subjects, samples. genetically characterized first time Panama 2015.