High Exogenous Antioxidant, Restorative Treatment for Prevention of Heart Failure: The Heart Diet

• DOI: 10.20944/preprints202206.0257.v1
• Publication Date: 2022-06-20T06:25:29Z
• Authors: Ram B. Singh; Jan Fedacko; Dominik Pella; Daniel Pella; Ghizal Fatima; Yulia Gushchina; Aminat Magomedova; Galal Elkilany; Mahmood Moshiri; Krassimira Hristova; Viliam Mojto; Patrik Jakabcin; Natalia Vanova
• Keywords: Lipotoxicity; Mediterranean Diet

Heart failure (HF) has become a public health problem, but exact pathophysiology is still unknown. Western diet characterised with high sugar, fat, red meat and processed meat, eggs, fried foods sweetened beverages, may cause oxidative stress inflammation, leading to dysfunction adverse effects on cardiac-ultra-structure. However, only little known about function of the myocardium how predispose Ca-overloading resulting in physio-pathological remodelling HF. Antioxidants such as flavonoids polyphenolics, omega-3 fatty acids, vitamins, minerals well essential nonessential amino acids that are rich Indo-Mediterranean type diets, have protective roles maintaining functions heart. The cardiac cells use glucose for metabolic depending upon physiological requirements. Apart from glucotoxicity, lipotoxicity also damaging which worsen presence deficiency endogenous antioxidants lower exogenous diet. There increased production ceramide, advanced glycation end products (AGE) triamino-methyl-N-oxide (TMAO) due sugar fat Ca-overloading. biological changes begin pathological damages. High combination inducible nitric oxide synthase (NOSi) via N-arginine methyl ester been found preserve ejection fraction mouse model It possible supplementation Exogenous Antioxidant Restorative Treatment (HEART) diet; polyphenolics flavonoids, minerals, arginine, cessation egg further improve cells, prevention improvement earliest Six Stages Cohort studies randomised, controlled trials would be necessary demonstration role HEART management