Evaluation of Anterior and Posterior Corneal Higher Order Aberrations for the Detection of Keratoconus and Suspect Keratoconus

• DOI: 10.20944/preprints202209.0105.v1
• Publication Date: 2022-09-08T05:26:10Z
• Authors: Abdelrahman Salman; Obeda Kailani; John Marshall; Marwan Ghabra; Ashraf Armia Bala...; Taym R. Darwish; Abdul Aziz Badla; Hala Alhaji
• Keywords: Coma (optics)

Aim: To investigate the application of anterior and posterior corneal higher order aberrations (HOAs) in detecting keratoconus (KC) suspect (SKC). Method: This is a retrospective, case-control study which evaluated non-ectatic (normal) eyes, SKC KC eyes. The Sirius Scheimpfug (CSO, Italy) analyzer was used to measure HOAs surfaces. Sensitivity, specificity area under receiver operating characteristic curve (AUC) were calculated. Results: Two-hundred twenty eyes included analysis (normal n = 108, n= 42, 70). Receiver (ROC) revealed high predictive ability for parameters: Root mean square (RMS) total HOAs, RMS trefoil coma detect (AUC > 0.9 all). Coma (3, ±1) derived from surface parameter with highest discriminate between normal 0.922; cutoff 0.2). All parameters insufficient discriminating < 0.8 In contrast, their excellent AUC all except spherical 0.846). Conclusion: Anterior can differentiate level certainty. disease however, only particular coma-like aberrations, are value. Corneal aberrometry may be value screening populations prevalence disease.