An Old Acquaintance. Could Adenovirus be our Next Pandemic Threat?

• DOI: 10.20944/preprints202212.0422.v1
• Publication Date: 2022-12-22T08:43:51Z
• Authors: Gustavo Enrique S...; Daniel Conei; Luis Lizama; Daniela Vargas; Luis Fidel Avendaño; Sandra Ampuero
• Keywords: Pandemic; Coronavirus; Respiratory tract

Human adenoviruses are one of the most important pathogens detected in acute respiratory diseases pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for first time oropharyngeal lymphatic tissue. To date, more than 85 types HAdV have been described, with different cellular tropisms. They can cause gastrointestinal symptoms, even urinary tract inflammation, although infections asymptomatic. However, there is a population at risk that develop serious lethal conditions. These viruses double-stranded DNA genome, 25-48 kbp, 90 nm diameter, without mantle, stable environment, resistant to fat-soluble detergents. Currently diagnosis made lateral flow immunochromatography or molecular biology through polymerase chain reaction. The objective this review recognize variability HAdV, pandemic potential recombinant could present between HAdV-3 7 viral types, known produce aggressive outbreaks health facilities. determined characteristics from infection treatment, vaccine development evaluation social determinants associated guiding necessary measures future sanitary control, preventing disasters such as SARS-CoV-2 pandemic.