Opposing Roles of FACT for Euchromatin and Heterochromatin in Yeast

• DOI: 10.20944/preprints202301.0458.v1
• Publication Date: 2023-01-26T09:26:13Z
• Authors: Shinya Takahata; Yota Murakami
• Keywords: Euchromatin; Heterochromatin protein 1; Chromodomain

DNA is stored in the nucleus of a cell folded state; however, only necessary genetic information extracted from required group genes. The key to extracting chromatin ambivalence. Depending on chromosomal region, characterized into low-density "euchromatin" and high-density "heterochromatin", with various factors being involved its regulation. Here, we focus regulation gene expression by yeast FACT complex, which functions both euchromatin heterochromatin. known as histone H2A/H2B chaperone initially reported an elongation factor associated RNA polymerase II. In budding yeast, activates promoter interacting transcriptional activators SBF/MBF via G1/S cycle fission plays important role formation higher-order structures repression binding Swi6, HP1 family protein, at This property, refers alternate chromatin-regulation depending partner, interesting phenomenon. Further analysis nucleosome within heterochromatin expected future studies.