Targeting Nociceptors and Transient Receptor Potential Channels for the Treatment of Migraine

• DOI: 10.20944/preprints202304.0492.v1
• Publication Date: 2023-04-19T00:36:54Z
• Authors: Cinder Faith Cohen; Jueun Roh; Sang Hoon Lee; Chul-Kyu Park; Temugin Berta
• Keywords: Nociceptor; Meninges; Triptans

Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe nociceptors in trigeminal ganglia play key role pain signals migraine. These innervate intracranial meninges and convey from to thalamus. Targeting these considered promising due their accessibility distinct molecular profile, which includes expression several transient receptor potential (TRP) channels. channels have been linked various conditions, including This review discusses mechanisms migraine, challenges current antimigraine drugs, evidence for well-studied emerging TRP channels, particularly TRPC4, as novel targets migraine prevention treatment.