Antigenic Cartography Indicates That Omicron BA.1 and BA.4/BA.5 Variants Remain Antigenically Distant to Ancestral SARS-CoV-2 After Sputnik V Vaccination Followed by Homologous (Sputnik V) or Heterologous (Comirnaty) Revaccination

• DOI: 10.20944/preprints202305.1591.v1
• Publication Date: 2023-05-24T02:10:51Z
• Authors: Ekaterina A Astak...; Alexey A Morozov; Maria G Byazrova; Maria M Sukhova; Artem A Mikhailov; Andrey A Gorchakov; Alexander V Filatov
• Keywords: Heterologous

Rapid emergence of evasive SARS-CoV-2 variants is an on-going challenge for COVID-19 vaccinology. Traditional virus neutralization tests provide detailed datasets titers against the viral variants. Such are difficult to interpret and do not immediately inform on sufficiency breadth antibody response. Some these issues could be tackled using antigenic cartography approach. In this study, we created maps sera from donors who received Sputnik V booster vaccine after primary vaccination compared them with based serum Comirnaty-boosted donors. analysis WT, Alpha, Beta, Delta, Omicron BA.1 BA.4/BA.5 showed a significant humoral response both homologous (Sputnik V) heterologous (Comirnaty) revaccinations all studied However, despite this, more in-depth revealed that remain antigenically distant which indicative formation insufficient levels cross-neutralizing antibodies. The implications findings may when developing new regimen.