Zn-Doped Calcium Magnesium Phosphate Bone Cements Based on Struvite and Their Antibacterial Properties

• DOI: 10.20944/preprints202305.2101.v1
• Publication Date: 2023-05-31T05:33:27Z
• Authors: Polina A. Krokhic...; Margarita A. Gold...; Alexander S. Fomin; Dinara R. Khayrut...; Olga S. Antonova; Alexander S. Baikin; Aleksander V. Leonov; Ekaterina M. Merz...; Ivan V. Mikheev; Valentina A. Kirs...; Irina K. Sviridova; Suraya A. Akhmedova; Natalia S. Sergeeva; Sergey M. Barinov; Vladimir S. Komlev
• Keywords: Struvite; Magnesium phosphate; Bone cement

The development of magnesium calcium phosphate bone cements (MCPCs) have garnered big attention. MCPCs are bioactive and biodegradable appropriate mechanical antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 1.0 wt.% were obtained investigated. After mixing liquid, structural phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, vitro behaviour materials examined. A high strength 48 ± 5 MPa (mean SD) was achieved made from 1.0-wt.%-substituted powders. introduction led to activity against Staphylococcus aureus Escherichia coli strains, an inhibition zone diameter up 8 mm. Biological assays confirmed that developed cytocompatible promising as potential substitute