<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

• DOI: 10.20944/preprints202306.0544.v1
• Publication Date: 2023-06-08T00:56:39Z
• Authors: Mehmet Emin Arayıcı; Yasemin Basbinar; Hulya Ellidokuz
• Keywords: Lower risk

It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose this paper was to elucidate Vit-D intake serum 25-hydroxyvitamin-D (25(OH)D) cancer incidence mortality, current evidence in field, biases using meta-meta-analysis method. Meta-analyses focusing intake, 25(OH)D levels, risk/mortality were identified. A structured computer literature search performed PubMed/Medline, Web Science (WoS), Scopus electronic databases predetermined keyword combinations. Primary secondary meta-meta-analyses carried out, combining odds ratios (ORs), risk (RRs), hazard (HRs) for outcomes reported selected meta-analyses. total 35 eligible meta-analyses assessing association between and/or mortality included study. In pooled analysis, higher associated with lower (OR = 0.93, 95% CI: 0.90-0.96, p &amp;lt; 0.001; OR 0.80, 0.72-0.89, 0.001, respectively) cancer-related (RR 0.89, 0.86-0.93, RR 0.67, 0.58-0.78, respectively). When whose primary reports only randomized controlled trials pooled, there no significant 0.99, 0.97-1.01, 0.320). subgroup consumption decrease colorectal lung 0.83-0.96, 0.002; 0.88, 0.83-0.94, Taken together, both may provide remarkable benefits terms however, careful evaluation according types critically important recommended.