Changing Epidemiology of Viral Hepatitis in a Post-Soviet Country – the Case of Kyrgyzstan

• DOI: 10.20944/preprints202307.0307.v1
• Publication Date: 2023-07-06T05:35:35Z
• Authors: Manas K. Akmatov; Nurgul J. Beisheeva; Asylbek Z. Nurmatov; Gulsunai J. Satta...; Saikal N. Kylychb...; Aisuluu A. Derken...; Zamira O. Abdrahm...; Jana Prokein; Norman Klopp; Thomas Illig; Omor T. Kasymov; Zuridin S. Nurmatov; Frank Pessler
• Keywords: Seroprevalence; Viral Hepatitis; Cross-sectional study

Historically, viral hepatitis is a considerable public health problem in Central Asian countries, which may have worsened after dissolution of the Soviet Union. However, up-to-date seroepidemiological studies are lacking. The aim present study was, therefore, to provide current estimates seroprevalence Kyrgyzstan, one economically least developed countries region. We conducted population-based cross-sectional 2018 capital Bishkek (n=1075). Participants, children and adults, were recruited from an outpatient clinic. Data collected during face-to-face interviews. A blood sample (6 ml) was each participant tested with ELISA for presence serological markers five hepatitides (A, B, C, D E). Poststratification weighting performed obtain nationally representative findings. overwhelming majority participants positive anti-HAV (estimated seroprevalence, 75.3%; 95% confidence interval: 72.5–77.9%). weighted HBsAg, anti-HCV anti-HDV 2.2% (1.5–3.3%), 3.8% (2.8–5.1%), 0.40% (0.15–1.01%), respectively. Anti-HEV seropositivity 3.3% (2.4–4.5%). Of 33 HBsAg participants, (15%) positive. Our confirms that Kyrgyzstan remains high endemic country virus C infections. seroprevalences HBV HDV lower than previously reported, based on these data, could potentially be reclassified (lower) intermediate endemicity. observed anti-HEV resembles low endemicity pattern characteristic high-income countries.