Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain

• DOI: 10.20944/preprints202307.1560.v1
• Publication Date: 2023-07-26T00:39:25Z
• Authors: Carmela L Marciano; Taylor A Hiland; Krista L. Jackson; Sierra Street; Carson Maris; Andrew Ehrsam; Julia M Hum; Terry Loghmani; Tien-Min Gabriel Chu; Kyung S Kang; Jonathan Lowery
• Keywords: Brief Report; 3. Good health

Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves medication, but there need for non-pharmacological non-invasive interventions. Soft tissue manipulation (STM) such as massage has been shown to be effective in human subjects, the molecular mechanisms underlying these findings are not well understood. In this paper, we evaluated potential changes soft levels of more than thirty pro- or anti-inflammatory cytokines following instrument-assisted STM (IASTM) rats with chronic, induced LBP using Complete Freund’s Adjuvant. Our results indicate IASTM associated reduced RANTES/CCL5 increased IL-4, which pro-inflammatory factors, respectively, by 120 minutes post-treatment. was tissue-level CXCL5/LIX (the murine homologue IL-8), CXCL7, GM-CSF ICAM-1, IL1-ra, IL-6, IP-10/CXCL10, L-selectin, TNF-α, VEGF at either 30- Combined, our suggest exerts effects improved clinical outcomes potentially beneficial pro/anti-inflammatory circulation level.