VACCINATON POLICIES IN SOLID ORGAN TRANSPLANT ADULT CANDIDATES AND RECIPIENTS

• DOI: 10.20944/preprints202307.1805.v1
• Publication Date: 2023-07-27T00:28:06Z
• Authors: Mauro Viganò; Marta Beretta; Marta Lepore; Raffaele Abete; Simone Vasilij Be...; Maria Vittoria Gr...; Stefania Camagni; Greta Chiodini; Simone Vargiu; Claudia Vittori; Marco Iachini; Amedeo Terzi; Flavia Neri; Domenico Pinelli; Fabiano Di Marco; Piero Ruggenenti; Marco Rizzi; Michele Colledan; Stefano Fagiuoli

Prevention of infections is crucial in solid organ transplant (SOT) candidates and recipients. These pa-tients are exposed to an increased infectious risk due to previous organ insufficiency and to pharmaco-logic immunosuppression. Besides infectious-related morbidity and mortality, this vulnerable group of patients is also exposed to the risk of acute decompensation and organ rejection or failure in the pre- and post-transplant period respectively, since antimicrobial treatments are less effective than in the immunocompetent patients. Vaccination represents a major preventive measure against specific infec-tious risks in this population but as responses to vaccines are reduced, especially in the early post-transplant period or after treatment for rejection, an optimal vaccination status should be obtained prior to transplantation whenever possible. This review reports the currently available data on the indications and modalities of vaccination in SOT adult candidates and recipients.