Polyarteritis Nodosa Reviewed in 2023: Old Disease, New Etiologies

• DOI: 10.20944/preprints202310.0949.v1
• Publication Date: 2023-10-17T03:19:12Z
• Authors: Louis Wolff; Alice Horisberger; Laura Moi; Maria P. Karampetsou; Denis Comte
• Keywords: Polyarteritis Nodosa; Etiology; Necrotizing Vasculitis

Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can involve smaller vessels. The clinical presentation heterogeneous characterized by significant number patients exhibiting general symptoms including asthenia, fever, unintended weight loss. Although PAN virtually any organ, preferentially the skin, nervous system, gastrointestinal tract. Orchitis rare but specific manifestation PAN. absence granulomas, glomerulonephritis ANCA serves distinguish from other type vasculitis. Major complications consist hemorrhagic thrombotic events occurring in mesenteric, cardiac, cerebral, renal systems. Historically, was frequently linked hepatitis B virus (HBV) infection, this association has dramatically changed recent years due declining HBV prevalence. Current epidemiological research often identifies connection between genetic syndromes well neoplasia. This article provides comprehensive review PAN, specifically focusing on progression its manifestations over time.