Fructooligosaccharides Supplementation: A Good Choice for Prevention and Treatment of Non-alcoholic Fatty Liver Disease?

• DOI: 10.20944/preprints202311.0376.v1
• Publication Date: 2023-11-08T02:29:41Z
• Authors: Priscila Nogueira...; Heric Holland; Bárbara Ferreira ...; Paula Payão Ovídio; Livia Maria Corde...; Alceu Afonso Jordão
• Keywords: QH301-705.5; fructooligosaccharides (FOS); QD415-436; Biology (General); prebiotics; hyperlipidic diet; Biochemistry; non-alcoholic fatty liver disease (NAFLD); TP248.13-248.65; Biotechnology

Carbohydrates such as fructooligosaccharides (FOS) are associated with improved gastrointestinal health and prevention of excess body fat. We evaluated the long-term effects high amounts FOS on metabolic parameters, non-alcoholic fatty liver disease (NAFLD) short-chain acids (SCFA). Sixty C57BL/6 mice received diets for four months: control (C), normolipid rich in fiber (F), supplemented (FOS), fat (HL), (HLF) (HLFOS). analyzed: animal weight; composition; food intake; fasting blood glucose; serum lipid profile; intestinal histologies; malondialdehyde (MDA), hepatic retinol α-tocopherol; SCFA feces. Supplementation a high-fat diet promoted less weight gain reduced retroperitoneal adipose tissue weights compared to HL HF. prevented NASH decreased alanine aminotransferase cholesterol levels experimental models obesity syndrome (MS). There was found statistical differences dosages three main SCFAs feces (acetic, isobutyric isovaleric acids). Long-term supplementation doses effective reducing weight, adiposity, NAFLD C57BL MS induced by diet.