Assessing the <em>In Vitro</em> Cytotoxicity, Antitumoral and Antioxidant Properties of Polyphenol‐rich <em>Perilla leaves </em>Extracts

• DOI: 10.20944/preprints202311.1599.v1
• Publication Date: 2023-11-27T02:02:17Z
• Authors: Gigi Adam; Florina Daniela C...; Liliana Verestiuc; Oana Cioanca; Ingrid Andrada Va...; Ana-Maria Adam; Cornelia Mircea; Aurel Nechita; Valeriu Romulus H...; Bogdan Huzum; AnaMaria Harabor; Monica Hancianu
• Keywords: Perilla frutescens; Perilla; Pro-oxidant

(1) Background: This study aimed to outline the antitumoral, antioxidant, and cytotoxic proprie-ties of various types Perilla frutescens extracts obtained from leaves species; (2) Methods: We determined total polyphenols, flavonoids anthocyanins contents, as well in vitro actions 3 ethanolic (E1, E2, E3) ethanol: acetone (A1, A2, A3) according standardized procedures; (3) Results: found that had higher phenol concentrations (p= 0.002). Flavonoids were not statistically different between two extracts. The iron chelating capacity, hydroxyl radical scavenging superoxide anion lipoxygenase inhibition capacity showed a significant increase with extracts, particularly Perillyl alcohol greater on MG-63 cell line E1 extract similar effects A431 line; (4) Conclusions: Both exhibited important antioxi-dant antitumoral vitro, which proportionally increased concentration. threshold this for could help determine best dosage maximum antioxidant potential.