Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

• DOI: 10.20944/preprints202312.0651.v2
• Publication Date: 2024-01-30T03:09:42Z
• Authors: Jan Jakub Lica; Katarzyna Gucwa; Mateusz Heldt; Anna Stupak; Natalia Maciejewska; Natalia Ptaszyńska; Anna Łęgowska; Bhaskar Pradhan; Agata Gitling-Dom...; Dawid Dębowski; Joanna Jakóbkiewi...; Krzysztof Rolka
• Keywords: Antiparasitic

The fusion of penetrating peptides (PPs), e.g., cell penetration (CPPs), or antimicrobial (AMPs) together with agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, well valuable anticancer proving beneficial in the development conjugates. resulting conjugates offer potential dual functionality, acting both agent. This especially necessary cancer treatment where microbial infections pose a critical risk. Leukemic cells frequently exhibit altered outer lipid membranes compared to healthy cells, making them more sensitive compounds that interfere their membrane. In this communication, we revisited reanalyzed our earlier on LfcinB its Furthermore, carried out new experiments specific focus proliferation, changes membrane asymmetric phosphatidylserine location, intracellular reactive oxygen species (ROS) generation, mitochondrial functions, vitro bacterial topoisomerase inhibition.