HIV-Infected Hepatic Stellate Cells or HCV-Infected Hepatocytes Are Unable to Promote Latency Reversal among HIV-Infected Mononuclear Cells

• DOI: 10.20944/preprints202312.1623.v1
• Publication Date: 2023-12-22T00:59:41Z
• Authors: Cinthya Alicia Ma...; Rosa Nicole Freib...; Franco Agustin Sv...; Jorge Quarleri; María Victoria De...
• Keywords: Hepatic stellate cell

Due to a common mode of transmission through infected human blood, hepatitis C virus (HCV) and immunodeficiency (HIV) coinfection is relatively prevalent. In alignment with this, HCV co-infection associated an increased size the HIV reservoir in highly active antiretroviral therapy (HAART)-treated individuals. Hence, it crucial comprehend physiological mechanisms governing latency reactivation reservoirs. Consequently, our study delves into interplay between HCV/HIV liver cells its impact on modulation latency. 
 We utilized latently monocytic cell line (U1) T (J-Lat) found that mediators produced by infection hepatic stellate hepatocytes HCV, respectively, were incapable inducing reversal under studied conditions. This may favor maintenance among mononuclear liver. Further investigations are essential elucidate role interaction regulating and/or reactivation, providing physiologically relevant model for comprehending microenvironments vivo.