Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease

• DOI: 10.20944/preprints202401.0238.v1
• Publication Date: 2024-01-04T01:16:38Z
• Authors: Sonia Mota-Zamorano; Guadalupe García-...; Guillermo Gervasini
• Keywords: Hydroxyeicosatetraenoic acid; Epoxygenase

This review provides insight into the role that obesity, but especially mediators of adipose tissue, have in both renal disease and transplantation. In particular, we focus on functions leptin adiponectin, inflammatory with widely known clinical implications, as well arachidonic acid-derived eicosanoid metabolites. These latter compounds, epoxyeicosatrienoic (EETs) hydroxyeicosatetraenoic (HETEs) acids, which modulate liberation cytokines are generated epoxygenase pathway biotransformation via CYP450 enzymes. There is accumulating evidence suggesting EETs HETEs may a critical onset outcome chronic kidney Finally, also discuss reported effect presence genetic variants leptin, HETEs-related genes cause patients recipients. The levels tissue related compounds play remarkable transplant. Accordingly, novel therapeutic strategies being developed based modulation their concentrations various diseases.