Polymer Delivery Systems for Long-Acting Antiretroviral Drugs

• DOI: 10.20944/preprints202401.1535.v2
• Publication Date: 2024-01-24T09:07:26Z
• Authors: Mohammad Ullah Nayan; Sudipta Panja; Ashrafi Sultana; Lubaba A. Zaman; Lalitkumar K. Vora; Brady J. Sillman; Howard E. Gendelman; Benson Edagwa
• Keywords: name=Pharmaceutical Science; vaginal rings; /dk/atira/pure/subjectarea/asjc/3000/3003; name=Pharmaceutical Science; polymer; antiretroviral therapy; implants; HIV; Review; 02 engineering and technology; chronic infectious diseases; name=SDG 3 - Good Health and Well-being; RS1-441; Pharmacy and materia medica; prodrug nanoformulations; 615; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; long-acting formulations; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being; /dk/atira/pure/subjectarea/asjc/3000/3003; microarray patches; 0210 nano-technology

Long-acting (LA) drug-delivery system (DDS) successes are linked to their abilities to harness biocompatible polymers and materials for sustained and predictable release of therapeutic agents over an extended period of time. For human immune deficiency virus type one (HIV-1) infections, LA DDSs hold great promise in closing the gaps of daily oral therapy for treatment and prevention. Examples are Cabenuva, Apretude and Sunlenca, which have been shown to be safe and effective. Alternative promising drug delivery technologies such as implants, prodrugs, vaginal rings, and microarray patches are being explored to further meet patients’ needs. We posit that improved physicochemical properties of the formulation payloads and material chemistry design with optimal drug release kinetics holds the potential to optimize release profiles. Furthermore, for the treatment and prevention of HIV-1 infection, the landscape of LA medicines now in clinical or preclinical development offers hope that the strategic design of polymers will further improve upon controlled delivery of drugs to simplify dosing schedules.