Inflammation and Iron Profile in Children with Sickle Cell Disease in Cameroon: Frequency and Associated Factors

• DOI: 10.20944/preprints202403.1721.v1
• Publication Date: 2024-03-29T03:32:45Z
• Authors: Romaric Tuono De ...; Josué Simo Louokdom; Bernard Claude Ch...; Prosper Cabral Bi...; Claude Tayou Tagny; Constant Anatole ...

Background and objectives: sickle cell disease is the most common hemoglobinopathy in world. It considered to be a real public health problem. Sickle patients are subjected several factors causing inflammation such as iron metabolism. The study aimed look for children with Cameroon, identify associated inflammation, raise consequences patient including profile of hemogram. Materials methods: We conducted an analytical cross-sectional 03 months. coming and/or followed at Hematology Department Regional Hospital Bafoussam Central Yaoundé have been recruited. exploration was made by determining CRP, IL6, ferritin concentrations. hematological parameters were evaluated using standard methods. Statistical analysis data performed; Univariate multivariate logistic regression analyses allowed identification patients, statistical tool R version 4.1.1.. proportions compared chi-square test when expected numbers greater than 5 Fisher not. Results: frequency population 42.3%. Hyperferritinemia significantly (p<0.001) non-inflammatory (96.8% 76.7% respectively). Patients showed significant elevation (p<0.05). In addition, IL6 during respectively (Or = 4.96; 95% CI [1.15-36.42]; p=0.056) =6.23; [1.43-45.96]; p=0.030). Conclusions: elevated plasma effect patients. Hence need controlling latter necessary.