The Impact of a 6-Week Nordic Walking Training Cycle and a 14-Hour Intermittent Fasting on Disease Activity Markers and Serum Levels of Wnt Pathway-Associated Proteins in Patients with Multiple Myeloma

• DOI: 10.20944/preprints202404.0304.v1
• Publication Date: 2024-04-04T03:43:05Z
• Authors: Olga Czerwińska-L...; Małgorzata Żychowska; Artur Jurczyszyn; Joanna Kryst; Jakub Mirosław Deląg; Andżelika Borkowska; Joanna Reczkowicz; Tomasz Pałka; Przemysław Bujas; Anna Piotrowska
• Keywords: Sclerostin; Osteopontin; Bone remodeling

Multiple myeloma (MM) accounts for about 10 to 15% of all diagnosed hematologic malignancies and 1-2% cancer cases. Approximately 80-90% MM patients develop bone disease the changes rarely regress. It is only possible stop or slow their progression. A major role in destruction attributed Wnt signaling pathway, its action can be modified by various types interventions including training diet. Therefore, aim this project was evaluate effects a Nordic Walking (NW) cycle intermittent fasting (IF) on levels selected turnover markers associated with pathway MM. Results from 35 divided into (NW IF NW) non-training (IF control) groups were included analysis. 6-week involving 60-minute workouts 3 times week conducted. Body mass composition of: vitamin D, calcium phosphorus, beta2-microglobulin albumin examined before after completion cycle. Markers also determined: sclerostin (SOST), Dickkopf-related protein 1 (DKK-1), osteoprotegrin (OPG), osteopontin (OPN) Tartrate-resistant acid phos-phatase 5b (TRACP 5b). There no negative effect combined nutritional status (the level albumines unchanged). Both showed an increase serum concentrations active metabolite D NW NW: p=0.001 p=0.022, re-spectively). The change concentration negatively correlated con-centration TRACP (r=-0.413, p=0.014). Evaluating related turnover, reduction SOST (time: p=0.026, time vs. group: p=0.033) p