Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics

• DOI: 10.20944/preprints202404.0413.v1
• Publication Date: 2024-04-10T09:22:36Z
• Authors: Reinis Rutkis; Zane Lasa; Marta Rubina; Inese Strazdina; Uldis Kalnenieks
• Keywords: Zymomonas mobilis; Energetics

Relative to several model bacteria, the ethanologenic bacterium Zymomonas mobilis is shown here have an elevated resistance exogenous antimicrobial peptides (AMPs) – both, with regard peptide bulk concentration in medium, and numbers of molecules per cell. By monitoring integration AMPs bacterial cell membrane observing resulting effect on energy-coupling, it concluded that membranotropic effects tested Z. Escherichia coli are comparable. The advantage over E. apparently results from its uncoupled mode energy metabolism that, contrast coli, does not rely oxidative phosphorylation, hence, less vulnerable disruption energy-coupling by AMPs. It high observed only proves crucial for survival natural environment but also offers a promising platform AMP production sheds light potential strategies novel development clinical settings.