Subclinical Maternal Pathologies with Clinical Manifestation in the Offspring

• DOI: 10.20944/preprints202408.1471.v1
• Publication Date: 2024-08-22T00:30:12Z
• Authors: Adriana Mihaela Dan; Diana Iulia Vasil...; Sorin Vasilescu; Vlad Dima; Monica Cirstoiu
• Keywords: Subclinical infection

It is documented that maternal diseases or treatments influence a newborn’s clinical status at birth; autoimmune with circulating antibodies are often clinically expressed transiently in newborns due to the crossover of specific IgG through placenta during pregnancy. The offspring can inherit genetic anomalies, but expression usually becomes patent later life. If prenatal medical history not available if signs symptoms mother’s disease revealed for first time pregnancy postpartum, their effects on newborn may be misattributed. In this article, we present three cases pregnant women, without any known pathology before pregnancy, who gave birth very sick preterm required admission Neonatal Intensive Care Unit (NICU). neonates’ complications were considered initially as consequences prematurity infection, investigations transient two (myasthenia gravis and hyperthyroidism) severe form thrombophilia third case. all cases, mothers asymptomatic unaware subclinical disease. Preemies’ diagnosis has contributed identification mothers’ adequate treatment was prescribed favourable short- long-term outcomes. one gravis) both mother child had associated infectious perinatal period complicated picture created problems diagnosis. This article intends emphasize paramount importance care, newborn. Repeated visits throughout good opportunity detect predispositions. As develop non-specific signs, should have experience pay attention differentiate among etiologies. Our paper takes reversed approach usual pathway: from infant instead towards infant, proving inter-speciality collaboration work bi-directionally.