A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses

• DOI: 10.20944/preprints202409.1379.v1
• Publication Date: 2024-09-19T00:52:46Z
• Authors: Zoë Jäckel; Ahmed Adžemović; Benedikt Kloos; Stefanie Hardung; Rita Sanchez-Bran...; Philippe Coulon; Ilka Diester
• Keywords: Carprofen

Effective pain management in laboratory animals is crucial for both animal welfare and the reliability of scientific research. We retrospectively examined effects carprofen as post-operative analgesia Sprague Dawley rats following stereotactic surgery. Our data indicate that administering twice daily (5 mg/kg), currently recommended by GV-SOLAS, led to adverse such reduced food water intake, disrupted fecal excretion, abdominal bloating consistent with peritonitis. Continued administration exacerbated these symptoms, post-mortem findings intestinal obstructions ulcers. However, when frequency was once daily, symptoms were not observed. These results are based on incidental collected from various neuroscientific experiments, resulting small uneven sample groups across experimental cohorts. The inherent imbalances present challenges statistical interpretation. While suggest less frequent use may reduce effects, surgical interventions concurrent other drugs experiments likely outcomes. Further investigation into interactions between carprofen, stress, perioperative factors needed refine protocols animals. Despite limitations, observations contribute understanding assist improving practices.