Hormone Replacement Therapy and Its Relationship with Skeletal Muscle Mass and Bone Mineral Density in Women from Western Mexico: Cross-Sectional Study

• DOI: 10.20944/preprints202411.0616.v1
• Publication Date: 2024-11-11T02:40:46Z
• Authors: Reynaldo Arellano...; Jorge Ivan Gamez-...; Felipe Alexis Ava...; Sergio Antonio Go...; Ernesto Javier Ra...; J. Ahuixotl Gutie...; Cesar Arturo Nava...; Fabiola Gonzalez-...; Norma Alejandra R...; Ana Miriam Saldañ...; Melissa Ramirez-V...; Eli Efrain Gomez-...; Miriam Fabiola Al...; Sylvia Elena Tots...; Ernesto Germán Ca...; Laura Gonzalez-Lopez; Juan Manuel Ponce...

Background: Every year, 1.5 million women worldwide experience menopause and the associated changes that cause disability and dysfunction. There are multiple treatments focused on the symptoms; hormone replacement therapy (HRT) may be one that helps us reduce these changes. Objectives: the objective of this work was to assess the relationship between skeletal muscle mass and bone mineral density in postmenopausal women using hormone replacement therapy. Methods: Study design: cross-sectional study. A systematic assessment of clinical charts from postmenopausal women using hormone replacement therapy. Differences between low muscle mass and low bone mineral density were assessed; linear regression models were calculated to estimated the effect of body mass index, length of menopause, age, presence of comorbidities, physical activity and muscle mass have over those variables. Results: Bone mineral density was heavily influenced level of body mass index (aẞ: 0.015, 95% CI, 0.010, 0.019, p<0.001) and age (aẞ: -0.006, 95% CI, -0.010, -0.002, p=0.002); while muscle mass changes were associated with body mass index (aẞ: 0.548, 95% CI, 0.456, 0.640, p<0.001) and Age (aẞ: -0.081, 95% CI, -0.155, -0.006, p=0.034) Conclusions: The use of Hormone replacement therapy does not have a relation with the levels of muscle mass neither bone mineral density in postmenopausal women.