Microbial Diversity in Drug Naïve Parkinson’s Disease Patients

• DOI: 10.20944/preprints202412.2135.v1
• Publication Date: 2024-12-26T01:01:46Z
• Authors: Eliša Papić; Valentino Rački; Mario Hero; Ana Nyasha Zimani; Gloria Rožmarić; Nada Starčević-Či...; Saša Ostojić; Miljenko Kapović; Goran Hauser; Aleš Maver; Borut Peterlin; Anja Kovanda; Vladimira Vuletić

Parkinson’s disease is a neurological disorder characterized by rigidity, bradykinesia and tremor. Several genetic environmental causes of are known, there emerging evidence the possible contribution gut microbiome to onset, severity, response therapy. While previous research has shown several differences in patients under therapy, few prospective studies have included drug naïve patients. In order evaluate composition prior therapy initiation, we collected performed 16S rRNA gene sequencing stool samples from 49 compared them 34 diet lifestyle-matched controls Croatian population (GiOPARK Project). no significant alpha diversity difference was observed between controls, differential relative abundance analysis showed an increase Bacteroides fluxus, B. interstinalis, eggerthii, Dielma fastidiosa while Alistipes, Barnesiella nd Dialister spp. were decreased controls. Insight into implementation represents valuable baseline dataset for further studies.