Congenital Oropouche in Humans: Clinical Characterization of a Possible New Teratogenic Syndrome

• DOI: 10.20944/preprints202502.1043.v1
• Publication Date: 2025-02-14T05:07:59Z
• Authors: Bethânia FR Ribeiro; André Rodrigues F...; Andre Pessoa; Raimunda do Socor...; Flávia de Freitas...; Bruna da Cruz Bey...; Natália Pimentel ...; Davi Dantas Muniz; Jannifer Oliveira...; Lucas Rosa Fraga; Fernanda Sales Lu...; Maria Teresa Viei...; Lilith Schuler Fa...; Fernanda Eduarda ...; Rafael da Silva A...; Livia Caricio Mar...; Livia Medeiros Ne...; Consuelo Silva Ol...; Pedro Fernando da...; Juarez Antônio Si...; Alberto Mantovani...; Vania de Mesquita...; Lucia Andreia Nun...; Simone de Menezes...; Giulia Radin; Miguel del Campo; Camila V Ventura; Lavinia Schuler-F...
• Keywords: Characterization

Oropouche fever is caused by the virus (OROV; Bunyaviridae, Orthobun-yavirus), one of most frequent arboviruses that infect humans in Brazilian Amazon. This year, an OROV outbreak was identified Brazil, and its vertical trans-mission reported, which associated with fetal death microcephaly. We describe clinical manifestations three cases congenital infec-tion confirmed serology (OROV-IgM) mother-newborn binomial. One newborns died, post-mortem molecular analysis using real-time RT-qPCR genome several tissues. All were born Amazon region mothers reported fever, rash, headache, myalgia, and/or retro-orbital pain during pregnancy. The presented severe mi-crocephaly secondary to brain damage arthrogryposis, suggestive em-bryo/fetal disruptive process at birth. Brain spinal images overlapping sutures, cerebral atrophy, cysts, thinning cord, corpus callosum, posterior fossa abnormalities. Fundoscopic findings included macular chorioretinal scars, focal pigment mottling, vascular attenuation. presentation infection resembled Zika syndrome some extent but pre-sents distinctive features on imaging aspects neurolog-ical presentation. A recognizable damage, neurological alterations, fundoscopic abnormalities can be in-utero infection.