Left Ventricular Global Function Index: A Potential Predictor of Mortality and Major Adverse Cardiovascular Events in NSTEMI Patients

• DOI: 10.20944/preprints202502.1224.v1
• Publication Date: 2025-02-19T00:18:17Z
• Authors: Mesut Karatas; Cengiz Sabanoglu; Kader Eliz Sahin; Ibrahim Halil Inanc
• Keywords: Ventricular Function

Background and Objectives: The Left Ventricular Global Function Index (LVGFI) is a comprehensive marker of cardiac performance that integrates volumetric functional parameters the left ventricle. While its prognostic value in chronic cardiovascular diseases well-documented, limited evidence exists for utility non-ST elevation myocardial infarction (NSTEMI). This study aimed to evaluate LVGFI as predictor three-year mortality major adverse events (MACE) NSTEMI patients. Methods: retrospective cohort included 432 patients divided into tertiles based on values: T1 (low), T2 (intermediate), T3 (high). values were derived from echocardiographic imaging. Kaplan-Meier survival analysis was used assess outcomes, Cox proportional hazards models, adjusted demographics clinical covariates (age, sex, body mass index, risk factors), determined association between outcomes. Results: average age sex distribution similar across (T1: 70 years, T2: 67 T3: 68 years) with no significant differences factors or most laboratory parameters, including glucose hematological counts. However, noted Body Surface Area (higher T3), platelet counts T1), triglyceride levels (lower T3). ROC identified an optimal cut-off 23.22 predicting mortality, sensitivity 72% specificity 75% (AUC: 0.81; 95% CI: 0.74-0.87, p < 0.001). Patients lowest tertile (T1) exhibited rate 25%, compared 2.1% highest (T3). After adjustment, hazard ratio (HR) significantly elevated (HR 11.86; 3.60-39.10) T3. Similarly, MACE rates (27.1%) (7.6%), underscoring LVGFI’s beyond traditional parameters. Conclusion: independent It offers holistic assessment function may enhance stratification models managing high-risk Further prospective studies are warranted validate broader utility.