<span style="mso-no-proof: yes;">The Toxicity of RNA Polymerase Inhibitors Opens the Door to New Drug Generation<span style="font-size: 10.0pt; mso-ansi-font-size: 18.0pt; font-family: 'Times New Roman',serif; mso-ascii-font-family: 'Palatino Linotype'; mso-hansi-font-family: 'Palatino Linotype'; font-weight: normal; mso-ansi-font-weight: bold;"> Modulating Longevity

• DOI: 10.20944/preprints202502.1509.v1
• Publication Date: 2025-02-21T00:15:06Z
• Authors: Ahmed Mohamed Helaly; Doaa Ghorab
• Keywords: Font

There are many RNA polymerase inhibitors, such as rifampicin, which acts an antituberculosis agent, and relatively new antiviral drugs, sofosbuvir. These drugs have a safe profile strong efficacy in treating tuberculosis hepatitis C infections. Studies shown that high doses of these compounds promote cell longevity (prolonging life span) humans. It is hypothesized also affect human polymerases at doses. We predicted inhibition inhibits the transcription machinery, considered pacemaker biological clock. important to shift research modulators develop versions diseases neurodegenerative disorders. Although there no data about crystal structure polymerase, mammalian even bacterial structures look conserved. raise concerns cancer risk from potential targeting polymerase. However, adding adjuvant therapy, vascular endothelial growth factor inhibitors can be wise strategy end tunnel. The speed elongation modulates longevity. Aging affects activity longevity, creating loop.