Safety Profile of <em>Solanum tuberosum</em>-Derived Exosomes: Evidence from In Vitro Experiments and Human Skin Tests

• DOI: 10.20944/preprints202502.1661.v1
• Publication Date: 2025-02-21T00:15:06Z
• Authors: YeJi Lee; Radwa Wahid Mohamed; Sanghwa Yang
• Keywords: Solanum tuberosum

Repetitive exposure to ultraviolet B (UVB) radiation is known cause DNA damage and increase levels of reactive oxy-gen species (ROS), which are linked the upregulation matrix metallopeptidases (MMPs) inflammatory cyto-kines. These events lead collagen breakdown by MMPs, resulting in wrinkles, loss elasticity, rough, dry skin—typical signs photoaging—and may even contribute skin cancers long term. We have previously shown that Solanum tuberosum-Derived Exosomes (SDE) can repress 80% expression MMP1 tissue necro-sis factor (TNF) at 50 μg/mL without inducing keratinocyte HaCaT cells. In this report, we show SDEs be treated cells up 1,000 cell death, establishing a safe maximum concen-tration. signifcantly promote wound healing scratch model wounds elevate ex-pression barrier genes fibroblast line Detroit 551, enhance integ-rity, prevent water loss, support natural desquamation. clinical test including 21 volunteers for 2 weeks, prototypes containing 100 as main ingredient significantly enhanced reduced deep eye wrinkle depth, decreased melanin content, most importantly, skin-irritating side effects. findings suggest safe, complex with antioxidant, anti-inflammatory, barrier-enhancing effects produced quantity relative ease potential medical application humans.