A Successful Experience of Individualized Vancomycin Dosing in Critically ill-Patients by Using Loading-Dose and Maintenance-Dose

• DOI: 10.20944/preprints202503.1556.v1
• Publication Date: 2025-03-24T01:03:16Z
• Authors: Jorge S Amador; Álvaro Vega; Patricio Araos; Luis Quiñones; Cristián A. Amador
• Keywords: Maintenance dose; Loading dose

Background/Objective: Vancomycin, a hydrophilic glycopeptide antibiotic with bactericidal activity against gram-positive microorganisms, is one of the most used antibiotics at intensive care units (ICU). Different efforts have been done to achieve therapeutically effective plasma concentration vancomycin by using loading and subsequent maintenance doses on an individual basis, but this remains debate. Our objective was individualize dosage regimen in Chilean ICU optimize pharmacological treatment population pharmacokinetic model. Methods: A quantitative-descriptive study carried out 51 patients adult ICU, San Borja Arriarán Clinical Hospital Santiago, Chile. The dose calculated software, Antibiotic Kinetics®, which subsequently validated levels drug through patient’s sample. Results: prescribed 1,500 mg 1,000 mg, 3 times day. measured blood concentrations each patient (16.98 ± 5.423 g/mL) were compared model (14.33 4.630 g/mL, p<0.05). Besides, correlation made between software trough versus for vancomycin, where positive both variables established (R2=0.65; p<0.0001). No renal side effects observed treated-patient group. Conclusions: In present study, dosing critically ill patients, based model, successfully implemented routine clinical practice.