Three-Body Problem in Stress Biology: Balance between O₂, NO, and H₂S in the Context of Hans Selye’s Stress Concept

• DOI: 10.20944/preprints202503.2047.v1
• Publication Date: 2025-03-28T00:52:39Z
• Authors: Hideo Yamasaki; Riko F Naomasa; Kakeru B Mizumoto; Michael F Cohen

Hans Selye’s stress concept, first introduced in the 1930s, has undergone substantial evolution, extending beyond biology and medicine to influence diverse academic dis-ciplines. Initially, General Adaptation Syndrome (GAS) described nonspecific physiological responses stressors exclusively mammals, without addressing other biological systems. Consequently, concept of developed independently bi-ology medicine, shaped by distinct contexts. This review provides a historical overview research, highlights both parallels divergences between plants animals, integrates insights from traditional Eastern philosophies. We propose an updated GAS framework that incorporates dynamic balance among reactive oxygen species (ROS), nitrogen (RNS), re-active sulfur (RSS) within broader context oxidative stress. To achieve holistic understanding stressors, we discuss ion-otropic glutamate receptors (iGluRs)—including N-methyl-D-aspartate (NMDARs) receptor-like channels (GLRs) plants, evolutionarily conserved transient receptor potential (TRP) channel superfamily—may represent minimal molecular underlying GAS. perspective expands classical paradigm, providing new into redox biology, in-terspecies adaptation, evolutionary physiology.