Antibacterial Activity of the p53 Tumor Suppressor Protein - How Strong Is the Evidence?

• DOI: 10.20944/preprints202504.0259.v1
• Publication Date: 2025-04-07T02:31:56Z
• Authors: Agnieszka Gdowicz...; Małgorzata Krześniak; Barbara Łasut-Szy...; Dorota Butkiewicz; Marek Rusin
• Keywords: P53 protein

p53 tumor suppressor is best known from controlling cell cycle, apoptosis, DNA repair, and metabolism, but it also regulates immunity able to impede the live cycle of viruses. For this reason these infectious agents encode proteins, which inactivate p53. However, what less that can be inactivated by human pathogenic bacteria. It probably not a collateral damage, specific targeting, because could interfere with their multiplication. The mechanisms antibacterial activity are poorly known. they inferred results high-throughput studies, identified more than thousand p53-activated genes. As turns out, many genes code proven or plausible functions like: efficient detection bacteria pattern recognition receptors, induction pro-inflammatory pyroptosis, recruitment immune cells, direct bactericidal presentation bacterial metabolites lymphocytes. Probably there antibacterial, p53-regulated functions, were overlooked laboratory animals kept in sterile conditions. In review we present outlines some intriguing p53, await further exploration. Definitely, area research deserves attention, especially light appearance antibiotic-resistant strains.