Microbial Signaling Networks: Bridging Cellular Communication with Applications in Health, Agriculture, and Biotechnology

• DOI: 10.20944/preprints202504.1833.v1
• Publication Date: 2025-04-24T02:40:27Z
• Authors: Abdullah Al Mamun; Shabiha Tasbir Ra...

Microorganisms utilize intricate chemical signaling mechanisms to communicate both within and across species, influencing a wide range of physiological behaviors ecological interactions. Among these mechanisms, quorum sensing stands out as pivotal strategy that bacteria employ detect population density coordinate gene expression in collective manner. These systems are mediated by autoinducers other secondary metabolites, such peptides, fatty acids, terpenoids, alkaloids. molecules not only facilitate intra- inter-species communication but also enable inter-kingdom interactions with host organisms, modulating immune responses, gut health, even cell fate decisions. Importantly, the understanding manipulation microbial signals have opened new frontiers biotechnology, particularly areas regenerative medicine, sustainable agriculture, antimicrobial therapy. This review provides comprehensive overview molecules, evolution cell-cell communication, role cellular microenvironment, emerging strategies for engineering functional responses. By elucidating pathways applications signaling, we propose innovative approaches convert non-functional or damaged cells into units, benefiting human health environmental sustainability.