Phototheranostics in the treatment of severe dysplasia and pre-invasive cervical cancer

• DOI: 10.20953/1726-1678-2024-1-5-15
• Publication Date: 2024-04-01T16:45:26Z
• Authors: A.V.Gilyadova A.V...; ; I.V.Reshetov I.V....; ; A.A.Ishchenko A.A...; ; A.I.Ishchenko A.I...; ; A.A.Shiryaev A.A....; ; S.I.Samoylova S.I...; ; M.F.Novruzalieva ...; ; N.V.Petukhova N.V...; ; P.M.Alekseeva P.M...; ; K.T.Efendiev K.T....; ; ; V.B.Loshchenov V....
• Keywords: Endocervical curettage; Cervical canal

Due to the high prevalence of pre-cancerous cervical diseases and cancer, search, pathogenetic reasoning evaluation efficacy new approaches diagnosis treatment these pathologies, including those aimed at fertility preservation, are extremely relevant. Objective. To study clinical safety phototheranostics as a method severe dysplasia pre-invasive cancer. Patients methods. An open-label, retrospective-prospective, randomized, comparative, trial involving 94 reproductive-aged patients with morphologically confirmed intraepithelial neoplasia (CIN) cancer was conducted. All were divided into two groups: group 1 (comparison) included 49 who underwent conization curettage remaining canal; 2 (study) 45 phototheranostics: photodynamic therapy (PDT) simultaneous laser-induced fluorescence excitation. Results. After first course phototheranostics, most women in had normal cytological results, which observed 6, 9, 12 months after treatment. In periods, all colposcopic picture, while comparison group, some showed signs lesions. Morphological confirmation complete therapeutic effect considered be elimination human papillomavirus (HPV) normalization proliferative activity epithelial layer (assessed by levels Ki-67 phosphohistone markers) during phototheranostics. Conclusion. The demonstrated CIN cancer: 85–88% achieved desired session second session, regression mucosal higher pregnancy rates favourable outcomes planning that use PDT contributes preservation treated for is associated anatomo-functional characteristics cervix when using Key words: PDT, HPV, therapy, diagnosis, dysplasia, photosensitizers,