Impact of frailty markers on outcomes after transcatheter aortic valve replacement: insights from a Japanese multicenter registry

• DOI: 10.21037/acs.2017.09.06
• Publication Date: 2017-09-30T09:40:51Z
• Authors: Tetsuro Shimura; Masanori Yamamoto; Seiji Kano; Ai Kagase; Atsuko Kodama; Yutaka Koyama; Toshiaki Otsuka; Shun Kohsaka; Norio Tada; Futoshi Yamanaka; Toru Naganuma; Motoharu Araki; Shinichi Shirai; Kazuki Mizutani; Minoru Tabata; Hiroshi Ueno; Kensuke Takagi; Akihiro Higashimori; Yusuke Watanabe; Kentaro Hayashida
• Keywords: Hypoalbuminemia

There are no standardized criteria for measuring patients' frailty. We examined prognosis based on four frailty markers [serum albumin level, grip strength, gait speed, and clinical scale (CFS)] in patients who underwent transcatheter aortic valve replacement (TAVR) between October 2013 April 2016 were recorded the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry. Serum level was assessed by dividing into two groups: hypoalbuminemia or non-hypoalbuminemia according to their serum level. Clinical outcomes including all-cause, cardiovascular non-cardiovascular mortality rates after TAVR compared. During follow-up period cumulative significantly higher group than group. This result remained unchanged even a propensity-matched model used terms of all-cause mortality; however, differences attenuated. To consider impact strength divided low high peak classification regression tree (CART) survival analysis. The each sex compared groups. In both sexes 1-year different investigate speed classified groups (low group) CART rate effect CFS assessed. Patients categorized five following scores: CFS1-3, CFS4, CFS5, CFS6, ≥7. evaluated relationship score other indicators markers. also mid-term among had significant correlation with increased an increasing score. Cox multivariable analysis, independent predictive factor late risk. conclusion, results suggest that all useful when considering optimal indications risk stratification TAVR.