Pulmonary hypertension associated mortality in the United States from 2003 to 2020: an observational analysis of time trends and disparities

• DOI: 10.21037/jtd-22-1468
• Publication Date: 2023-06-29T09:33:46Z
• Authors: Harpreet Singh; Lipisha Agarwal; Chinmay Jani; Padmanabh Bhatt; Adam Hartley; Joseph Shalhoub; Jonathan S. Kurman; Omar Al Omari; Alaaeldin Ahmed; Dominic C. Marshall; Justin D. Salcicc...
• Keywords: 330; 610; Original Article; 3. Good health

Pulmonary hypertension (PH) is an independent risk factor for morbidity and mortality. In the last two decades, significant advances have been made in management of World Health Organization (WHO) group 1 PH. However, there are no approved targeted pharmacotherapies PH secondary to left-sided heart diseases or chronic hypoxic lung which thought account more than 70-80% disease burden. No recent investigation has analyzed compared mortality burden related WHO with groups 2-5 at national level United States (US). We hypothesize that PH-related improved over decades comparison PH.In this study, we used data from Centers Disease Control Prevention Wide-ranging Online Data Epidemiologic Research (CDC WONDER) underlying cause death database study age-standardized rates US 2003 2020.A total 126,526 deaths were recorded between 2020. Across period, ASMR increased 17.81 per million population 23.89 2020 a percentage change (PC) +34%. contrasting trends when demonstrated decline regardless gender. contrast, increase was observed, accounting major proportion overall years.PH-related continues primarily due attributed These findings notable public health implications. Screening assessment tools PH, modification, novel strategies vital improve outcomes.