HOXA5-induced lncRNA DNM3OS promotes human embryo lung fibroblast fibrosis via recruiting EZH2 to epigenetically suppress TSC2 expression

• DOI: 10.21037/jtd-23-1145
• Publication Date: 2024-02-23T09:02:00Z
• Authors: Hong Lv; Xingjia Qian; Zhengzheng Tao; Jun Shu; Dongfang Shi; Jing Yu; Guiqin Fan; Qiuhong Qian; Luhong Shen; Bing Lu
• Keywords: Chromatin immunoprecipitation

Idiopathic pulmonary fibrosis (IPF) is an unrepairable disease that results in lung dysfunction and decreased quality of life. Prevention challenging, while its pathogenesis remains largely unknown. Herein, we investigated the effect mechanism long non-coding RNA (lncRNA)