The biomechanical effect of the O-A angle on the aortic valve under left ventricular assist device support: a primary fluid-structure interaction study

• DOI: 10.21037/jtd-24-1650
• Publication Date: 2024-12-31T01:14:11Z
• Authors: Weining Wang; Xiaoyu Ren; Qinxin Xue; Hussein Sliman; Bin Gao; Shu Li; Yu Chang; Youjun Liu

Left ventricular assist device (LVAD) has been widely used as an alternative treatment for heart failure, however, aortic regurgitation is a common complication in patients with LVAD support. And the O-A angle (the between outflow graft and aorta) considered vital factor associated function of valve. To date, biomechanical effect on valve remains largely unknown. The aim this study was to evaluate how influence properties. current employed novel fluid-structure interaction (FSI) model that integrates Lattice Boltzmann method (LBM) finite element (FEM) investigate under status evaluated at three different angles (45, 90 135 degrees) and. four indicators, including stress distribution, mean stress, axial hemodynamic force (AHF) wall shear (WSS) distribution were timepoints (28, 133, 266 ms). results showed high-stress region leaflets increased difference left pressure (LVP) (AP) increased. insufficiency observed 28 ms (systolic phase) 135-degree angle. During systolic phase, significant fluctuation when or degrees. diastolic conditions LVP AP Regarding AHF, obvious during phase (0-100 ms) AHF For WSS evaluation, At phase), high located free edge leaflets, deformed 133 rapid 45 degrees, both belly closely A large caused well broad thus leading retrograde flow. Therefore, optimization will favor maintain function.