Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

• DOI: 10.21037/jtd.2017.01.17
• Publication Date: 2017-01-23T12:05:33Z
• Authors: Regina Aleksonienė; Ingrida Zeleckienė; Mindaugas Matačiūnas; Roma Puronaitė; Laimutė Jurgauskienė; Radvilė Malickaitė; Edita Strumilienė; Vygantas Gruslys; Rolandas Zablockis; Edvardas Danila
• Keywords: Ground-glass opacity; Extrinsic Allergic Alveolitis

Background: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead optimize patient follow-up frequency. Methods: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, function tests (PFT), bronchoscopy bronchoalveolar lavage (BAL) and lung biopsy, fluid (BALF) cell examination. Results: reduction in PFT values seen radiological sarcoidosis stage III greater than that stages I II. percentage neutrophils lungs found increase II III. indices were correlated negatively consolidation ground glass opacities CT scores, but not micronodule or macronodule scores. rise BALF lymphocytes associated restriction pattern PFT. diagnostic value for higher when typical patterns disease smoking decreased CD4/CD8 ratio. Conclusions: This supports opinion staging X-rays is still valuable from point view, because significant correlations between parameters found. Chest HRCT significantly superior X-ray detecting mediastinal parenchymal changes. However, role needs be better investigated evaluating serial examinations. Only scores (neither are frequently sarcoidosis) hold value, since these parameters.