Impact of cyclooxygenase-2 and prostaglandin-E2 expression on clinical outcome after pulmonary metastasectomy

• DOI: 10.21037/jtd.2017.02.83
• Publication Date: 2017-03-30T15:43:15Z
• Authors: Christian Lang; Emilie Hrdliczka; Thomas Schweiger; Olaf Glueck; Gerrit Lewik; Stefan Schwarz; Alberto Benazzo; György Lang; Walter Klepetko; Konrad Hoetzenecker
• Keywords: Metastasectomy

Pulmonary metastasectomy (PM) is a standard procedure in the treatment of stage IV colorectal cancer (CRC). In most centers indication for PM solely based on clinical factors without taking tumor biology into account. This results diverse outcomes ranging from long-term remission to early recurrence. Inflammation considered hallmark development and progression. On other hand accessibility CRC cells immune system reflects grade aggressiveness. We sought investigate impact cyclooxygenase-2 (COX-2) prostaglandin-E2 (PGE2) expression pulmonary metastases different outcome parameters following PM.From 04/2009 11/2013 53 patients with complete were included this single-center study. Tissue samples resected available corresponding primaries collected assessed by immunohistochemistry COX-2 PGE2 tissue peritumoral stroma. Results correlated parameters.COX-2 detected nearly every metastasis. Staining intensities only weakly found primary tumors. When dividing high expressing low tumors, trend towards longer recurrence free survival improved was tumors strong staining.In conclusion, pilot study shows that are uniformly overexpressed CRC. High seems reflect beneficial late prolonged overall after PM.