Bronchial hyperreactivity in perimenstrual asthma is associated with increased Th-2 response in lower airways

• DOI: 10.21037/jtd.2017.06.121
• Publication Date: 2017-07-31T00:56:47Z
• Authors: Szymon Skoczynski; Aleksandra Semik-...; Ewa Sozanska; Wojciech Szanecki; Krzysztof Kołodzi...; Igor Radziewicz-W...; Andrzej Witek; Władysław Pierzchała; Adam Barczyk
• Keywords: Bronchial hyperreactivity; Small airways

Perimenstrual asthma (PMA) is a commonly observed, usually difficult-to-treat phenotype. The mechanisms underlying this phenomenon remain unexplained. aim of the study was to assess degree airway hyperresponsiveness and its relationship proinflammatory cytokines concentration in lower airways PMA compared non-PMA patients.Premenopausal women with regular menstrual cycles diagnosed as: (n=12), asthmatics (n=9), healthy controls (n=10) were prospectively followed for 10 weeks over two consecutive cycles. bronchial responsiveness (BR) test methacholine performed each subject prior study. serum total immunoglobulin E (IgE) concentrations taken sputum induced 26th day Sputum eotaxin, IL-4 IL-10 measured by ELISA.Levels BR metacholine as well, blood IgE subjects significantly higher than (P=0.001, P=0.022 respectively) correlated other (P=0.030; r =-0.65). eotaxin luteal phase increased patients when (P=0.016; P=0.041, (P<0.001 both cytokines). No differences levels among studied groups seen.BR level perimenstrual correlates concentration. associated shift type-1/type-2 cytokine balance toward type-2 response.